| Date | Home | Away | Result |
|---|---|---|---|
| 12/17/21 1:30 PM | FC Bayern Munich | VfL Wolfsburg | 4-0 |
| 12/18/21 8:30 AM | 1899 Hoffenheim | Bor. Mönchengladbach | 1-1 |
| 12/18/21 8:30 AM | Eintracht Frankfurt | FSV Mainz 05 | 1-0 |
| 12/18/21 8:30 AM | RB Leipzig | Arminia Bielefeld | 0-2 |
| 12/18/21 8:30 AM | SpVgg Greuther Fürth | FC Augsburg | 0-0 |
| 12/18/21 8:30 AM | VfL Bochum | 1. FC Union Berlin | 0-1 |
| 12/18/21 11:30 AM | Hertha BSC | Borussia Dortmund | 3-2 |
| 12/19/21 8:30 AM | SC Freiburg | Bayer 04 Leverkusen | 2-1 |
| 12/19/21 10:30 AM | 1. FC Köln | VfB Stuttgart | 1-0 |