| Date | Home | Away | Result |
|---|---|---|---|
| 12/10/21 1:30 PM | 1. FC Köln | FC Augsburg | 0-2 |
| 12/11/21 8:30 AM | RB Leipzig | Bor. Mönchengladbach | 4-1 |
| 12/11/21 8:30 AM | FC Bayern Munich | FSV Mainz 05 | 2-1 |
| 12/11/21 8:30 AM | VfL Bochum | Borussia Dortmund | 1-1 |
| 12/11/21 8:30 AM | Hertha BSC | Arminia Bielefeld | 2-0 |
| 12/11/21 8:30 AM | SC Freiburg | 1899 Hoffenheim | 1-2 |
| 12/11/21 11:30 AM | VfL Wolfsburg | VfB Stuttgart | 0-2 |
| 12/12/21 8:30 AM | SpVgg Greuther Fürth | 1. FC Union Berlin | 1-0 |
| 12/12/21 10:30 AM | Eintracht Frankfurt | Bayer 04 Leverkusen | 5-2 |