| Date | Home | Away | Result |
|---|---|---|---|
| 12/3/21 1:30 PM | 1. FC Union Berlin | RB Leipzig | 2-1 |
| 12/4/21 8:30 AM | FSV Mainz 05 | VfL Wolfsburg | 3-0 |
| 12/4/21 8:30 AM | 1899 Hoffenheim | Eintracht Frankfurt | 3-2 |
| 12/4/21 8:30 AM | Bayer 04 Leverkusen | SpVgg Greuther Fürth | 7-1 |
| 12/4/21 8:30 AM | Arminia Bielefeld | 1. FC Köln | 1-1 |
| 12/4/21 8:30 AM | FC Augsburg | VfL Bochum | 2-3 |
| 12/4/21 11:30 AM | Borussia Dortmund | FC Bayern Munich | 2-3 |
| 12/5/21 8:30 AM | VfB Stuttgart | Hertha BSC | 2-2 |
| 12/5/21 10:30 AM | Bor. Mönchengladbach | SC Freiburg | 0-6 |