| Date | Home | Away | Result |
|---|---|---|---|
| 11/4/22 2:30 PM | Bor. Mönchengladbach | VfB Stuttgart | 3-1 |
| 11/5/22 9:30 AM | Borussia Dortmund | VfL Bochum | 3-0 |
| 11/5/22 9:30 AM | 1899 Hoffenheim | RB Leipzig | 1-3 |
| 11/5/22 9:30 AM | FSV Mainz 05 | VfL Wolfsburg | 0-3 |
| 11/5/22 9:30 AM | FC Augsburg | Eintracht Frankfurt | 1-2 |
| 11/5/22 9:30 AM | Hertha BSC | FC Bayern Munich | 2-3 |
| 11/5/22 12:30 PM | Werder Bremen | FC Schalke 04 | 2-1 |
| 11/6/22 8:30 AM | Bayer 04 Leverkusen | 1. FC Union Berlin | 5-0 |
| 11/6/22 10:30 AM | SC Freiburg | 1. FC Köln | 2-0 |