| Date | Home | Away | Result |
|---|---|---|---|
| 11/26/21 1:30 PM | VfB Stuttgart | FSV Mainz 05 | 2-1 |
| 11/27/21 8:30 AM | 1. FC Köln | Bor. Mönchengladbach | 4-1 |
| 11/27/21 8:30 AM | Hertha BSC | FC Augsburg | 1-1 |
| 11/27/21 8:30 AM | VfL Wolfsburg | Borussia Dortmund | 1-3 |
| 11/27/21 8:30 AM | SpVgg Greuther Fürth | 1899 Hoffenheim | 3-6 |
| 11/27/21 8:30 AM | VfL Bochum | SC Freiburg | 2-1 |
| 11/27/21 11:30 AM | FC Bayern Munich | Arminia Bielefeld | 1-0 |
| 11/28/21 8:30 AM | Eintracht Frankfurt | 1. FC Union Berlin | 2-1 |
| 11/28/21 10:30 AM | RB Leipzig | Bayer 04 Leverkusen | 1-3 |