| Date | Home | Away | Result |
|---|---|---|---|
| 11/19/21 1:30 PM | FC Augsburg | FC Bayern Munich | 2-1 |
| 11/20/21 8:30 AM | Bor. Mönchengladbach | SpVgg Greuther Fürth | 4-0 |
| 11/20/21 8:30 AM | Bayer 04 Leverkusen | VfL Bochum | 1-0 |
| 11/20/21 8:30 AM | Borussia Dortmund | VfB Stuttgart | 2-1 |
| 11/20/21 8:30 AM | Arminia Bielefeld | VfL Wolfsburg | 2-2 |
| 11/20/21 8:30 AM | 1899 Hoffenheim | RB Leipzig | 2-0 |
| 11/20/21 11:30 AM | 1. FC Union Berlin | Hertha BSC | 2-0 |
| 11/21/21 8:30 AM | SC Freiburg | Eintracht Frankfurt | 0-2 |
| 11/21/21 10:30 AM | FSV Mainz 05 | 1. FC Köln | 1-1 |