| Date | Home | Away | Result |
|---|---|---|---|
| 10/21/22 1:30 PM | FSV Mainz 05 | 1. FC Köln | 5-0 |
| 10/22/22 8:30 AM | SC Freiburg | Werder Bremen | 2-0 |
| 10/22/22 8:30 AM | 1899 Hoffenheim | FC Bayern Munich | 0-2 |
| 10/22/22 8:30 AM | FC Augsburg | RB Leipzig | 3-3 |
| 10/22/22 8:30 AM | Borussia Dortmund | VfB Stuttgart | 5-0 |
| 10/22/22 8:30 AM | Bayer 04 Leverkusen | VfL Wolfsburg | 2-2 |
| 10/22/22 11:30 AM | Bor. Mönchengladbach | Eintracht Frankfurt | 1-3 |
| 10/23/22 8:30 AM | VfL Bochum | 1. FC Union Berlin | 2-1 |
| 10/23/22 10:30 AM | Hertha BSC | FC Schalke 04 | 2-1 |