| Date | Home | Away | Result |
|---|---|---|---|
| 10/14/22 1:30 PM | FC Schalke 04 | 1899 Hoffenheim | 0-3 |
| 10/15/22 8:30 AM | Eintracht Frankfurt | Bayer 04 Leverkusen | 5-1 |
| 10/15/22 8:30 AM | VfB Stuttgart | VfL Bochum | 4-1 |
| 10/15/22 8:30 AM | VfL Wolfsburg | Bor. Mönchengladbach | 2-2 |
| 10/15/22 8:30 AM | Werder Bremen | FSV Mainz 05 | 0-2 |
| 10/15/22 11:30 AM | RB Leipzig | Hertha BSC | 3-2 |
| 10/16/22 8:30 AM | 1. FC Köln | FC Augsburg | 3-2 |
| 10/16/22 10:30 AM | 1. FC Union Berlin | Borussia Dortmund | 2-0 |
| 10/16/22 12:30 PM | FC Bayern Munich | SC Freiburg | 5-0 |