| Date | Home | Away | Result |
|---|---|---|---|
| 10/29/21 1:30 PM | 1899 Hoffenheim | Hertha BSC | 2-0 |
| 10/30/21 8:30 AM | Arminia Bielefeld | FSV Mainz 05 | 1-2 |
| 10/30/21 8:30 AM | SC Freiburg | SpVgg Greuther Fürth | 3-1 |
| 10/30/21 8:30 AM | 1. FC Union Berlin | FC Bayern Munich | 2-5 |
| 10/30/21 8:30 AM | Bayer 04 Leverkusen | VfL Wolfsburg | 0-2 |
| 10/30/21 8:30 AM | Borussia Dortmund | 1. FC Köln | 2-0 |
| 10/30/21 11:30 AM | Eintracht Frankfurt | RB Leipzig | 1-1 |
| 10/31/21 9:30 AM | FC Augsburg | VfB Stuttgart | 4-1 |
| 10/31/21 11:30 AM | Bor. Mönchengladbach | VfL Bochum | 2-1 |