| Date | Home | Away | Result |
|---|---|---|---|
| 8/13/21 1:30 PM | Bor. Mönchengladbach | FC Bayern Munich | 1-1 |
| 8/14/21 8:30 AM | VfL Wolfsburg | VfL Bochum | 1-0 |
| 8/14/21 8:30 AM | 1. FC Union Berlin | Bayer 04 Leverkusen | 1-1 |
| 8/14/21 8:30 AM | VfB Stuttgart | SpVgg Greuther Fürth | 5-1 |
| 8/14/21 8:30 AM | FC Augsburg | 1899 Hoffenheim | 0-4 |
| 8/14/21 8:30 AM | Arminia Bielefeld | SC Freiburg | 0-0 |
| 8/14/21 11:30 AM | Borussia Dortmund | Eintracht Frankfurt | 5-2 |
| 8/15/21 8:30 AM | FSV Mainz 05 | RB Leipzig | 1-0 |
| 8/15/21 10:30 AM | 1. FC Köln | Hertha BSC | 3-1 |