| Date | Home | Away | Result |
|---|---|---|---|
| 11/17/22 7:15 PM | Green Bay Packers | Tennessee Titans | 17-27 |
| 11/20/22 12:00 PM | Atlanta Falcons | Chicago Bears | 27-24 |
| 11/20/22 12:00 PM | Buffalo Bills | Cleveland Browns | 31-23 |
| 11/20/22 12:00 PM | New York Giants | Detroit Lions | 18-31 |
| 11/20/22 12:00 PM | New Orleans Saints | Los Angeles Rams | 27-20 |
| 11/20/22 12:00 PM | Indianapolis Colts | Philadelphia Eagles | 16-17 |
| 11/20/22 12:00 PM | New England Patriots | New York Jets | 10-3 |
| 11/20/22 12:00 PM | Baltimore Ravens | Carolina Panthers | 13-3 |
| 11/20/22 12:00 PM | Houston Texans | Washington Commanders | 10-23 |
| 11/20/22 3:05 PM | Denver Broncos | Las Vegas Raiders | 16-22OT |
| 11/20/22 3:25 PM | Pittsburgh Steelers | Cincinnati Bengals | 30-37 |
| 11/20/22 3:25 PM | Minnesota Vikings | Dallas Cowboys | 3-40 |
| 11/20/22 7:20 PM | Los Angeles Chargers | Kansas City Chiefs | 27-30 |
| 11/21/22 7:15 PM | Arizona Cardinals | San Francisco 49ers | 10-38 |