| Date | Home | Away | Result |
|---|---|---|---|
| 4/8/23 6:30 PM | New England Revolution | CF Montreal | 4-0 |
| 4/8/23 6:30 PM | Inter Miami CF | FC Dallas | 0-1 |
| 4/8/23 6:30 PM | Cincinnati FC | Philadelphia Union | 1-0 |
| 4/8/23 6:30 PM | D.C. United | Columbus Crew | 0-2 |
| 4/8/23 6:30 PM | New York Red Bulls | San Jose Earthquakes | 1-1 |
| 4/8/23 6:30 PM | New York City FC | Atlanta United FC | 1-1 |
| 4/8/23 6:30 PM | Los Angeles FC | Austin FC | 3-0 |
| 4/8/23 7:30 PM | Nashville SC | Toronto FC | 0-0 |
| 4/8/23 7:30 PM | Sporting Kansas City | Colorado Rapids | 0-1 |
| 4/8/23 7:30 PM | Chicago Fire | Minnesota United FC | 2-1 |
| 4/8/23 7:30 PM | Houston Dynamo | Los Angeles Galaxy | 3-0 |
| 4/8/23 8:30 PM | Real Salt Lake | Charlotte FC | 3-1 |
| 4/8/23 9:30 PM | Vancouver Whitecaps | Portland Timbers | 1-0 |
| 4/8/23 9:30 PM | Seattle Sounders | St. Louis City SC | 3-0 |