| Date | Home | Away | Result |
|---|---|---|---|
| 4/1/23 6:30 PM | Philadelphia Union | Sporting Kansas City | 0-0 |
| 4/1/23 6:30 PM | New England Revolution | New York City FC | 1-1 |
| 4/1/23 6:30 PM | Orlando City | Nashville SC | 0-2 |
| 4/1/23 6:30 PM | Columbus Crew | Real Salt Lake | 4-0 |
| 4/1/23 6:30 PM | Los Angeles Galaxy | Seattle Sounders | 1-2 |
| 4/1/23 6:30 PM | Atlanta United FC | New York Red Bulls | 1-0 |
| 4/1/23 6:30 PM | Cincinnati FC | Inter Miami CF | 1-0 |
| 4/1/23 6:30 PM | Toronto FC | Charlotte FC | 2-2 |
| 4/1/23 7:30 PM | FC Dallas | Portland Timbers | 1-1 |
| 4/1/23 7:30 PM | Chicago Fire | D.C. United | 0-0 |
| 4/1/23 7:30 PM | St. Louis City SC | Minnesota United FC | 0-1 |
| 4/1/23 8:30 PM | Colorado Rapids | Los Angeles FC | 0-0 |
| 4/1/23 9:30 PM | Vancouver Whitecaps | CF Montreal | 5-0 |
| 4/1/23 9:30 PM | San Jose Earthquakes | Houston Dynamo | 2-1 |