| Date | Home | Away | Result |
|---|---|---|---|
| 3/18/23 3:00 PM | Seattle Sounders | Los Angeles FC | 0-0 |
| 3/18/23 6:30 PM | Toronto FC | Inter Miami CF | 2-0 |
| 3/18/23 6:30 PM | CF Montreal | Philadelphia Union | 3-2 |
| 3/18/23 6:30 PM | Atlanta United FC | Portland Timbers | 5-1 |
| 3/18/23 6:30 PM | New York Red Bulls | Columbus Crew | 2-1 |
| 3/18/23 6:30 PM | New England Revolution | Nashville SC | 1-0 |
| 3/18/23 6:30 PM | Orlando City | Charlotte FC | 1-2 |
| 3/18/23 6:30 PM | New York City FC | D.C. United | 3-2 |
| 3/18/23 7:30 PM | St. Louis City SC | San Jose Earthquakes | 3-0 |
| 3/18/23 7:30 PM | FC Dallas | Sporting Kansas City | 2-1 |
| 3/18/23 7:30 PM | Houston Dynamo | Austin FC | 2-0 |
| 3/18/23 7:30 PM | Chicago Fire | Cincinnati FC | 3-3 |
| 3/18/23 8:30 PM | Colorado Rapids | Minnesota United FC | 1-2 |
| 3/18/23 9:30 PM | Los Angeles Galaxy | Vancouver Whitecaps | 1-1 |