| Date | Home | Away | Result |
|---|---|---|---|
| 5/17/23 6:30 PM | Cincinnati FC | CF Montreal | 3-0 |
| 5/17/23 6:30 PM | Toronto FC | New York Red Bulls | 0-0 |
| 5/17/23 6:30 PM | Orlando City | New York City FC | 1-1 |
| 5/17/23 6:30 PM | Philadelphia Union | D.C. United | 0-0 |
| 5/17/23 6:30 PM | Charlotte FC | Chicago Fire | 2-1 |
| 5/17/23 6:30 PM | Columbus Crew | Los Angeles Galaxy | 2-0 |
| 5/17/23 6:30 PM | Atlanta United FC | Colorado Rapids | 4-0 |
| 5/17/23 7:30 PM | FC Dallas | Vancouver Whitecaps | 2-1 |
| 5/17/23 7:30 PM | Minnesota United FC | Houston Dynamo | 1-0 |
| 5/17/23 7:30 PM | Nashville SC | Inter Miami CF | 2-1 |
| 5/17/23 8:30 PM | Real Salt Lake | Portland Timbers | 0-0 |
| 5/17/23 9:30 PM | Seattle Sounders | Austin FC | 1-2 |
| 5/17/23 9:30 PM | Los Angeles FC | Sporting Kansas City | 1-1 |