| Date | Home | Away | Result |
|---|---|---|---|
| 5/13/23 12:00 PM | Chicago Fire | St. Louis City SC | 1-0 |
| 5/13/23 6:30 PM | Columbus Crew | Orlando City | 2-2 |
| 5/13/23 6:30 PM | Atlanta United FC | Charlotte FC | 1-3 |
| 5/13/23 6:30 PM | CF Montreal | Toronto FC | 2-0 |
| 5/13/23 6:30 PM | D.C. United | Nashville SC | 1-1 |
| 5/13/23 6:30 PM | Inter Miami CF | New England Revolution | 2-1 |
| 5/13/23 6:30 PM | New York Red Bulls | New York City FC | 1-0 |
| 5/13/23 7:30 PM | Sporting Kansas City | Minnesota United FC | 3-0 |
| 5/13/23 7:30 PM | Houston Dynamo | Seattle Sounders | 0-1 |
| 5/13/23 7:30 PM | Austin FC | FC Dallas | 0-1 |
| 5/13/23 8:30 PM | Colorado Rapids | Philadelphia Union | 1-2 |
| 5/13/23 8:30 PM | Real Salt Lake | Los Angeles FC | 0-3 |
| 5/13/23 9:30 PM | Portland Timbers | Vancouver Whitecaps | 3-1 |
| 5/14/23 8:30 PM | Los Angeles Galaxy | San Jose Earthquakes | 2-1 |