| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 4/9/24 5:00 PM | Gremio Porto Alegre | Huachipato | Group C | 0-2 |
| 4/9/24 5:00 PM | Estudiantes de La Plata | The Strongest | Group C | 2-1 |
| 4/9/24 7:00 PM | Club Libertad | Deportivo Tachira | Group H | 3-0 |
| 4/9/24 7:00 PM | Fluminense | Colo-Colo | Group A | 2-1 |
| 4/9/24 9:00 PM | Junior FC | Universitario | Group D | 1-1 |
| 4/10/24 5:00 PM | Club Atletico Mineiro | Rosario Central | Group G | 2-1 |
| 4/10/24 5:00 PM | Independiente del Valle | CA San Lorenzo | Group F | 2-0 |
| 4/10/24 5:00 PM | Club Cerro Porteno | Alianza Lima | Group A | 1-0 |
| 4/10/24 7:00 PM | Club Atlético Peñarol | Caracas FC | Group G | 5-0 |
| 4/10/24 7:30 PM | Flamengo | Palestino | Group E | 2-0 |
| 4/10/24 7:30 PM | FC Sao Paulo | Cobresal | Group B | 2-0 |
| 4/10/24 9:00 PM | Barcelona SC | CA Talleres | Group B | 2-2 |
| 4/11/24 5:00 PM | Club Bolívar | Millonarios FC | Group E | 3-2 |
| 4/11/24 5:00 PM | LDU Quito | Botafogo | Group D | 1-0 |
| 4/11/24 7:00 PM | River Plate | Club Nacional de Football | Group H | 2-0 |
| 4/11/24 7:00 PM | Palmeiras | Liverpool F.C. | Group F | 3-1 |