| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 4/18/23 5:00 PM | Fluminense | The Strongest | Group D | 1-0 |
| 4/18/23 5:00 PM | Internacional | Metropolitanos FC | Group B | 1-0 |
| 4/18/23 7:00 PM | Athletico Paranaense | Club Atletico Mineiro | Group G | 2-1 |
| 4/18/23 7:00 PM | Club Olimpia | CA Patronato Parana | Group H | 1-0 |
| 4/18/23 7:00 PM | Boca Juniors | Deportivo Pereira | Group F | 2-1 |
| 4/18/23 9:00 PM | Independiente del Valle | Liverpool F.C. | Group E | 2-0 |
| 4/19/23 5:00 PM | Club Nacional de Football | Independiente Medellín | Group B | 2-1 |
| 4/19/23 7:00 PM | River Plate | Sporting Cristal | Group D | 4-2 |
| 4/19/23 7:30 PM | Flamengo | Ñublense | Group A | 2-0 |
| 4/19/23 7:30 PM | Corinthians | Argentinos Juniors | Group E | 0-1 |
| 4/19/23 8:00 PM | Colo-Colo | Monagas SC | Group F | 1-0 |
| 4/19/23 9:00 PM | Barcelona SC | Club Bolívar | Group C | 2-1 |
| 4/20/23 5:00 PM | Racing Club | SD Aucas | Group A | 3-2 |
| 4/20/23 7:00 PM | Palmeiras | Club Cerro Porteno | Group C | 2-1 |
| 4/20/23 7:00 PM | Atlético Nacional | FBC Melgar | Group H | 3-1 |
| 4/20/23 9:00 PM | Club Libertad | Alianza Lima | Group G | 1-2 |